"Neuronal transporters regulate neurotransmitter supply and the vesicle cycle at inhibitory synapses "Stéphane Supplisson  Ph.D -2016.4.8

時間:     2016年4月8日  上午10:00 am
地點：    中北校區 腦功能基因組學研究所一樓會議室
報告題目：Neuronal transporters regulate neurotransmitter supply and the vesicle cycle at inhibitory synapses
報告人： Stéphane Supplisson  Ph.D 
         IBENS Neuroscience Section,  Ecole normale supérieure de Paris
主持人：陳愛華 研究員

報告人簡介： Stéphane Supplisson Ph.D, Co-leader of the Inhibitory Transmission team at IBENS.
Dr. Supplission got his Ph.D. in Cellular Physiology in University Paris XI and finished his postdoctoral training in UCLA Physiology Department in 1993. Then he started his research career as researcher in INSERM and was promoted as senior researcher in INSERM in 2001. Since 2008,  he was Co-leader of the Inhibitory Transmission team at IBENS. His research interests were in Membrane Biology, Molecular Biophysics, transporters, electrophysiology, models, Neurobiology, Synaptic transmission and Synaptic vesicles. His research results were published on many first class academic Magazines (Neuron, PNAS, Journal of Neuroscience et.al ) and were awarded “Association Française contre les Myopathies” grants and Team “Fondation pour la Recherche Médicale” grant.

報告簡介：The synchronized release of neurotransmitters by exocytosis requires their prior storage inside synaptic vesicles. This filling step of the vesicle cycle remains largely unexplored for physi-ology and vesicle imaging to investigate what happens when neurons run out of neuro-transmitter. At inhibitory synapses, the captures of glycine, GABA and its precursors by neuronal transporters are critical for maintaining vesicle filling and signaling during repetitive activity. Surprisingly, evidence suggests that the neurotransmitter cycle and the vesicle cycle are not independent but interplay with each other to match the synaptic release of GABA or glycine with available metabolic resource.