"Hierarchical requirement of the exocytosis and other signaling pathways in dendrite growth and maintenance"彭云 博士（University of Washington）-2015.12.24

時間：2015年12月24日 10:00

地點：中北校區 腦功能基因組學研究所一樓會議室

報告題目：Hierarchical requirement of the exocytosis and other signaling pathways in dendrite growth and maintenance

報告人：彭云 博士 University of Washington

主持人：林龍年 教授

報告人簡介：University of Washington.  Yun Peng obtained Ph.D. degree in Neuroscience from the Institutes of Neuroscience, Chinese Academy of Sciences in Shanghai, to investigated the mechanisms of neuronal dendrite development and homeostasis, and the role of N-cadherin in neuronal activity-induced dendrite outgrowth . His postdoctoral research work was in Professor Wen-Cheng Xiong’s lab at Georgia Regents University to study the role of Myosin X in axon development. After completing the project, he joined Dr. Shenfeng Qiu’s lab at University of Arizona to investigate the molecular mechanisms underlying Autism related gene MET-induced dendrite defect. Now, He is in Dr. Jay Parrish’s lab at University of Washington to investigate the molecule mechanism underlying dendrite outgrowth. His research work showed the hierarchical requirement of the exocytosis pathway in dendrite growth and maintenance.

報告簡介：Dendrites lengthen by several orders of magnitude during neuronal development, but how membrane is allocated in dendrites to facilitate this growth remains unclear. Here, we report that Ras opposite (Rop), the Drosophila ortholog of the key exocytosis regulator Munc18-1, is an essential factor mediating dendrite growth. Neurons with depleted Rop function exhibit reduced terminal dendrite outgrowth followed by primary dendrite degeneration, suggestive of differential requirements for exocytosis in the growth and maintenance of different dendritic compartments. Rop promotes dendrite growth together with the exocyst, an octameric protein complex involved in tethering vesicles to the plasma membrane, with Rop-exocyst complexes and exocytosis predominating in primary dendrites over terminal dendrites. By contrast, membrane-associated proteins readily diffuse from primary dendrites into terminals, but not in the reverse direction, suggesting that diffusion, rather than targeted exocytosis, supplies membranous material for terminal dendritic growth, revealing key differences in the distribution of materials to these expanding dendritic compartments.