"NMDA receptors: molecular diversity, mechanisms and synaptic regulation "Pierre Paoletti 博士(法國INSERM研究所)-2014.5.28

時間：2014年5月28日 10:00

地點：腦功能一樓報告廳

報告題目：NMDA receptors: molecular diversity, mechanisms and synaptic regulation

報告人：Pierre Paoletti 博士 法國INSERM研究所

報告人簡介：法國INSERM研究所(National Institute of Health and Medical Research) Research Director，IBENS 研究所(Biology Institute of Ecole Normale Supérieure) Team leader。Pierre Paoletti 博士的主要研究興趣為NMDA受體的結構、藥理和功能，具體研究方向為解析NMDA受體作用的分子機理、亞基特有的藥理學特征以及在生理和藥理過程中，興奮性突觸的NMDA受體的內源性調節因素（如鋅離子）。其出色的研究成果發表在Nature, Neuron, Nature Neuroscience, Nature Structural & Molecular Biology, PNAS, EMBO Journal and Journal of Neuroscience等國際一流學術刊物上；并且受邀為Nature Reviews Neuroscience 以及 Current Opinion in Pharmacology雜志撰寫綜述文章。2010年，獲得歐洲神經科學學會FENS青年學者獎。

報告簡介：NMDA receptors (NMDARs) are glutamate-gated ion channels that are widely expressed in the central nervous system (CNS) and highly permeable to calcium ions. NMDARs have always attracted attention because of their central involvement in neuronal development and plasticity. These receptors are essential mediators of synaptic plasticity and their dysfunction is implicated in a variety of neurological and psychiatric disorders (stroke, chronic pain, neurodegenerative diseases, schizophrenia), although NMDAR-based therapeutics have yet to be turned into clinical successes. I will present current knowledge on the anatomical and functional diversity of NMDARs, their molecular architecture and structural mechanisms, and the recent identification of key regions that control their subunit-specific gating and pharmacological profile. I will also present results obtained with knock-in mice revealing how endogenous modulators, such as zinc ions, interact with specific NMDAR populations and regulate excitatory synapses and behavior. Finally, I will briefly discuss how information about NMDAR regulation may translate into the design of novel therapeutic agents.