"Foxg1 has an essential role in postnatal development of the Dentate Gyrus"趙春杰 博士（東南大學基礎醫學院）-2011.10.19

時間：2011年10月19日 10:00

地點：理科大樓A510

報告題目：Foxg1 has an essential role in postnatal development of the Dentate Gyrus

報告人：趙春杰 博士 東南大學基礎醫學院

報告人簡介：東南大學基礎醫學院，教授；國家杰出青年科學基金獲得者；2000年3月，獲東京大學醫學系研究科分子細胞生物學博士學位。2001年4月，在加里福尼亞大學舊金山分校(UCSF)作博士后，從事發育神經生物學的研究。研究成果發表于《Cell》、《Development》、《J. Neuroscience》等學術刊物上。2005年獲得國家杰出青年科學基金資助，2007年入選江蘇省中青年科技領軍人才。主要利用基因工程小鼠研究由于神經系統發育缺陷而導致的相關疾病的發病機理。負責承擔國家杰出青年基金、973重大項目和國家自然科學基金等多項研究項。

報告簡介：In mammals, neurogenesis occurs in the subgranular zone (SGZ) of the dentate gyrus (DG) throughout adulthood, and dentate neurogenesis is thought to be defective in many disorders. The mechanisms underlying early DG development and adult neurogenesis, however, are not well-understood. Foxg1, formerly BF-1, is expressed continuously in the postnatal and adult DG. This transcription factor (TF) is thought to be involved in Rett Syndrome (RS), which is characterized by reduced hippocampus size. This phenotype indicates an important role for Foxg1 in hippocampal development. The early functions of Foxg1 have been examined in the mouse cortex and adult hippocampus, but due to the perinatal death of Foxg1-/- mice, the function of Foxg1 in postnatal DG neurogenesis remains to be explored. In our research work, we report that Foxg1 is critical for SGZ formation and exerts differential effects on DG cell subtypes. In progenitors, Foxg1 promotes self-renewal, preventing their differentiation into glia and neurons. In postmitotic neurons, however, Foxg1 is required for survival and maturation.