"Synaptic and Circuitry Mechanisms of Obsessive Compulsive-like Behavior in Mice."Guoping Feng（McGovern Neuroscience Institute Massachusetts Institute of Technology, MA, USA）（McGovern Neuroscience Institute Massachusetts Institute of Technology, MA, USA）-2010.7.17

時間：2010年7月17日 10:00-11:30

地點：理科大樓A508

報告題目:"Synaptic and Circuitry Mechanisms of Obsessive Compulsive-like Behavior in Mice."

報告人：馮國平 博士（McGovern Neuroscience Institute Massachusetts Institute of Technology, MA, USA）

報告簡介：Obsessive-compulsive disorder (OCD) is an anxiety-spectrum disorder characterized by persistent intrusive thoughts (obsessions) and repetitive actions (compulsions). Dysfunction of cortico-striato-thalamo-cortical circuitry is implicated in OCD.  SAP90/PSD95-associated protein 3 (SAPAP3) is a postsynaptic scaffolding protein at excitatory synapses that is highly expressed in the striatum. Mice with genetic deletion of Sapap3 exhibit increased anxiety and compulsive grooming behavior.  Electrophysiological, structural and biochemical studies of Sapap3-mutant mice reveal defects in cortico-striatal synapses. Furthermore, lentiviral-mediated selective expression of Sapap3 in the striatum rescues the synaptic and behavioural defects of Sapap3-mutant mice. These findings demonstrate a critical role for SAPAP3 at cortico-striatal synapses and emphasize the importance of cortico-striatal circuitry in OCD-like behaviours.