汪小京 博士 計算神經科學、決策及工作記憶

腦功能基因組學教育部重點實驗室PI
電話：021-20595003
Email: xjwang@nyu.edu

研究方向
計算神經科學、決策及工作記憶

個人簡歷

汪小京教授現任紐約大學神經科學教授，及物理與數學兼職教授，并任紐約大學斯沃茨理論神經科學中心聯合主任。他同時是上海紐約大學科研副校長、華東師范大學- 紐約大學腦與認知科學聯合研究中心（上海紐約大學）主任。2012年至2014年，汪教授擔任上海紐約大學首位教務長。汪教授于2012年加入紐約大學，此前曾任耶魯大學神經生物學教授、耶魯大學斯沃茨理論神經科學中心主任、物理、應用數學系與心理學系兼職教授。

汪教授是理論與計算神經科學專家，研究重點是認知功能的腦機制，尤其以在工作記憶的細胞基礎、決策的神經機制、大腦抑制神經元網絡的研究而著稱。他的團隊開創了被稱為“大腦CEO”的前額葉皮質神經網絡模型研究。最近，汪教授的團隊正創建大型腦的神經系統仿真模型，來深入研究認知、行為的腦機制和計算原理。

汪教授曾以最優成績獲得比利時布魯塞爾大學的物理學學士學位與博士學位。他是阿爾弗雷德·斯隆研究學者獎、美國國家科學基金會CAREER獎、古根海姆紀念基金會學者獎、斯坦福大學行為科學高等研究中心學者獎獲得者。此外，汪教授還是美國科學促進會會士。

 

代表性成果

Selected publications:

1.     Wei W, Wang X-J (2016) Downstream effect of ramping neuronal activity through synapses with short-term plasticity. Neural Comput. 28:652-666. doi:10.1162/NECO_a_00818

2.     Song HF*, Yang GR*, Wang X-J (2016) (* equal contribution) Training excitatory-inhibitory recurrent neural networks for cognitive tasks: A simple and flexible framework. PLoS Comp. Bio. 12:e1004792. doi:10.1371/journal.pcbi.1004792

3.     Wang X-J, Kennedy H (2016) Brain structure and dynamics across scales: in search of rules. Curr. Opin. in Neurobio. 37:92-98. doi:10.1016/j.conb.2015.12.010

4.     Sarma A, Masse NY, Wang X-J, Freedman DJ (2016) Task-specific versus generalized mnemonic representations in parietal and prefrontal cortices. Nature Neuroscience 19:143–149. doi:10.1038/nn.4168

5.     Wei W, Wang X-J (2015) Impact of membrane bistability on dynamical response of neuronal populations. Phys. Rev. E 92:032726. doi:10.1103/PhysRevE.92.0327265

6.     Yang GJ, Murray JD, Wang X-J, Glahn DC, Pearlson GD, Repovs G, Krystal JH, Anticevic A (2015) Functional hierarchy underlies preferential connectivity disturbances in schizophrenia. Proc. Natl. Acad. Sci. USA 113:E219–E228. doi:10.1073/pnas.1508436113

7.     Lo C-C, Wang C-T, Wang X-J (2015) Speed-accuracy tradeoff by a control signal with balanced excitation and inhibition. Journal of Neurophysiology 114:650-661. doi:10.1152/jn.00845.2013

8.     Chaudhuri R, Knoblauch K, Gariel M-A, Kennedy H, Wang X-J (2015) A large-scale circuit mechanism for hierarchical dynamical processing in the primate cortex. Neuron 88, 419–431. doi:10.1016/j.neuron.2015.09.008

9.     Wei Z, Wang X-J (2015) Confidence estimation as a stochastic process in a neurodynamical system of decision making. J. Neurophys. 114, 99-113. doi:10.1152/jn.00793.2014

10.  Engel TA*, Chaisangmongkon W*, Freedman DJ, Wang X-J (2015) (* equal contribution). Choice-correlated activity fluctuations underlie learning of neuronal category representation. Nature Communications 6, 6454. doi:10.1038/ncomms7454

11.  Wei W, Rubin JE, Wang, X-J (2015) Role of the indirect pathway of the basal ganglia in perceptual decision making. J. Neurosci. 35, 4052-4064. doi:10.1523/JNEUROSCI.3611-14.2015

12.  Anticevic A, Hu X, Xiao Y, Hu J, Li F, Bi F, Cole MW, Savic A, Yang GJ, Repovs G, Murray JD, Wang X-J, Huang X, Lui S, Krystal JH, Gong Q (2015) Early-course unmedicated schizophrenia patients exhibit elevated prefrontal connectivity associated with longitudinal change. J. Neurosci. 35, 267. doi:10.1523/JNEUROSCI.2310-14.2015

13.  Wang X-J, Krystal JH (2014) Computational Psychiatry. Neuron, 84:638-654. doi:10.1016/j.neuron.2014.10.018

14.  Murray JD, Bernacchia A, Freedman DJ, Romo R, Wallis JD, Cai X, Padoa-Schioppa C, Pasternak T, Seo H, Lee D, Wang X-J (2014) A hierarchy of intrinsic timescales across primate cortex. Nature Neuroscience 17, 1661. doi:10.1038/nn.3862

15.  Song HF, Kennedy H, Wang X-J (2014) Spatial embedding of structural similarity in the cerebral cortex. Proc. Natl. Acad. Sci. USA 111, 16580. doi:10.1073/pnas.1414153111

16.  Pereira J, Wang X-J (2014) A tradeoff between accuracy and flexibility in a working memory circuit endowed with slow feedback mechanisms. Cerebral Cortex. doi:10.1093/cercor/bhu202

17.  Yang GJ*, Murray JD*, Repovs G, Cole MW, Savic A, Glasser MF, Pittenger C, Krystal JH, Wang X-J, Pearlson GD, Glahn DC, Anticevic A (2014) (* equal contribution) Altered global brain signal in schizophrenia. Proc. Natl. Acad. Sci. USA 111, 7438. doi:10.1073/pnas.1405289111

18.  Chaudhuri R, Bernacchia A, Wang X-J (2014) A diversity of localized timescales in network activity. eLife 2014;3:e01239. doi:10.7554/eLife.01239

19.  Ardid S, Wang X-J (2013) A Tweaking Principle for Executive Control: Neuronal Circuit Mechanism for Rule-Based Task Switching and Conflict Resolution. J. Neurosci. 33, 19504. doi:10.1523/JNEUROSCI.1356-13.2013

20.  Rigotti M, Barak O, Warden MR, Wang X-J, Daw ND, Miller EK, Fusi S (2013) The importance of mixed selectivity in complex cognitive tasks. Nature. doi:10.1038/nature12160

21.  Wang M, Yang Y, Wang C-J, Gamo NJ, Jin LE, Mazer JA, Morrison JH, Wang X-J, Arnsten AFT (2013) NMDA receptors subserve persistent neuronal firing during working memory in dorsolateral prefrontal cortex. Neuron 77, 736-749. doi:10.1016/j.neuron.2012.12.032

22.  Engel TA, Wang X-J (2011) Same or different? A neural circuit mechanism of similarity based pattern-match decision making. J. Neurosci., 31: 6982-6996

23.  Rigotti M, Ben Dayan Rubin DD, Wang X-J and Fusi S (2010) Internal representation of task rules by recurrent dynamics: the importance of the diversity of neural responses. Front. Comput. Neurosci., 4: 24. doi: 10.3389/fncom.2010.00024

24.  Wang X-J (2010) Neurophysiological and computational principles of cortical rhythms in cognition. Physiol. Rev., 90: 1195-1268

25.  Lo C-C and Wang X-J (2006) Cortico-basal ganglia circuit mechanism for a decision threshold in reaction time tasks. Nature Neurosci., 9: 956-963

26.  Wong K-F and Wang X-J (2006) A recurrent network mechanism of time integration in perceptual decisions. J. Neurosci., 26: 1314-1328

27.  Wang X-J, Tegner J, Constantinidis C, Goldman-Rakic PS (2004) Division of labor among distinct subtypes of inhibitory neurons in a cortical microcircuit of working memory. Proc. Natl. Acad. Sci. (USA), 101, 1368-1373

28.  Renart A, Song P and Wang X-J (2003) Robust spatial working memory through homeostatic synaptic scaling in heterogeneous cortical networks. Neuron, 38, 473-485

29.  Wang X-J (2002) Probabilistic decision making by slow reverberation in cortical circuits.  Neuron, 36, 955-968

30.  Wang X-J (1999b) Synaptic basis of cortical persistent activity: the importance of NMDA receptors to working memory. J. Neurosci. 19, 9587-9603.

 

Book chapters: 

1.     Wang X-J (2013) The prefrontal cortex as a quintessential “cognitive-type” neural circuit: working memory and decision making. Principles of Frontal Lobe Function, Edited by DT Stuss and RT Knight, Second Edition, Cambridge University Press, pp. 226-248.

2.     Wang X-J (2013) Neuronal circuit computation of choice, In Neuroeconomics: Decision Making and the Brain, Second Edition, edited by P. W. Glimcher, C. F. Camerer, E Fehr and R. A. Poldrack. Academic Press, pp. 435-453.

3.     Wang X-J (2010) Prefrontal Cortex. in Handbook of Brain Microcircuits, Edited by G Shepherd and S Grillner, Oxford University Press, New York, pp. 46-56.

4.     Wang X-J (2009) Introduction to Theoretical Neuroscience (in Chinese). Chapter 53, in Neuroscience, edited by Han Jiseng (《神經科學》 (第三版)，韓濟生主編), Beijing University press, pp. 1004-1019.