曹曉華 博士 突觸可塑性與行為研究
腦功能基因組學教育部重點實驗室PI
辦公電話：021-62237103
Email: xhcao@brain.ecnu.edu.cn
研究方向
學習記憶的分子神經機制及認知障礙的病理學機制
個人簡歷
2005 —至今 華東師范大學 腦功能基因組學教育部重點實驗室 副教授 研究員
2004 —2005 美國波士頓大學醫學院 藥理學系 訪問研究者
2003 —2004 美國普林斯頓大學 分子生物學系 訪問研究者
2001—2003 復旦大學神經生物研究所 博士后研究者
2000—2001 新疆師范大學 生物系 副教授 系主任
1996 —2000 華東師范大學 生物系 博士
學術任職/人才獲獎
美國神經科學學會會員，中國神經科學學會會員，生理學會會員
代表性成果
1. 科研成果
部分研究論文：
1) Jing Ma, Yanhong Duan, Zhenxia Qin, Jiayue Wang, Wenzhao Liu, Meichen Xu, Siqi Zhou, Xiaohua Cao* Overexpression of αCaMKII Impairs Behavioral Flexibility and NMDAR-Dependent LTD in the Medial Prefrontal Cortex. Neuroscience, 310, 528–540, 2015
2) Yanhong Duan, Siqi Zhou, Jing Ma, Pengcheng Yin, Xiaohua Cao*. Forebrain NR2B overexpression enhancing fear acquisition and long-term potentiation in the lateral amygdala. European Journal of Neuroscience. pp. 1-10, 2015.
3) Wei H#, Cao X#, Zeng Q, Zhang F, Xue Q, Luo Y, Lee JW, Yu B, Feng X. Ghrelin inhibits proinflammatory responses and prevents cognitive impairment in septic rats. Crit Care Med. 43(5):e143-50. doi: 10.1097/CCM.0000000000000930, 2015 ( #Co-first author)
4) Xuliang Zhang, Bo Wang, Jing Jin , Shuming An, Qingwen Zeng, Yanhong Duan, Liguo Yang, Jing Ma, Xiaohua Cao* Early deprivation reduced anxiety and enhanced memory in adult male rats. Brain Research Bulletin. 108, 44–50，2014.
5) Xin Guan, Yanhong Duan, Qingwen Zeng, Hongjie Pan, Yu Qian, Dali Li*, Xiaohua Cao*, Mingyao Liu*. Lgr4 Protein Deficiency Induces Ataxia-like Phenotype in Mice and Impairs Long Term Depression at Cerebellar Parallel Fiber-Purkinje Cell Synapses. J Biol Chem. 289(38):26492-504, 2014
6) Zhenzhong Cui, Ruiben Feng，Stephanie Jacobs, Yanhong Duan, Huimin Wang，Xiaohua Cao, Tsien, Joe Z. Increased NR2A:NR2B ratio compresses long-term depression range and constrains long-term memory.Scientific Reports. doi: 10.1038/srep01036.2012
7) Qingwen.Zeng、Jiao.Han、Bo.Wang、Shuming.An、Yanhong.Duan、Suzhen.Dong、Jin.Ma、L.Yang、Xiaohua Cao* Water Maze Spatial Learning Enhances Social Recognition Ability in Aged Rats. Neurophysiology, 44(6), pp 464-469, 2012
8) Suzhen Dong, Qingwen Zeng, E. Siobhan Mitchell, Jin Xiu, Yale Duan, Chunxia Li, Jyoti K. Tiwari, Yinghe Hu, Xiaohua Cao*, Zheng Zhao*. Curcumin Enhances Neurogenesis and Cognition in Aged Rats: Implications for Transcriptional Interactions Related to Growth and Synaptic Plasticity. PLoS ONE. 7(2): e31211. 2012
9) Yihui Cui, Jing Jin, Xuliang Zhang, Hao Xu, Liguo Yang, Dan Du, Qingwen Zeng, Joe Z. Tsien, Huiting Yu, Xiaohua Cao*. Forebrain NR2B Overexpression Facilitating the Prefrontal Cortex Long-Term Potentiation and Enhancing Working Memory Function in Mice. PLoS ONE. 6(5): e20312. 2011
10) Wen Si, Xuliang Zhang, Yan Niu, Huiting Yu, Xiaoping Lei, Huanxin Chen, Xiaohua Cao*. A novel derivative of xanomeline improves fear cognition in aged mice. Neuroscience Letters. 473:115-119. 2010
11) Deheng Wang, Zhenzhong Cui, Qingwen Zeng, Hui Kuang, L. Phillip Wang, Joe Z. Tsien*, Xiaohua Cao*. Genetic enhancement of memory and Long-Term Potentiation but not CA1 Long-Term Depression in NR2B transgenic rats. PLoS ONE. 4(10): e7486. 2009
12) Yihui Cui, Dong Wang, Wen Si, Wen Lv, Yan Niu, Xiaoping Lei, Yinhe Hu, Xiaohua Cao* Enhancement of memory function in aged mice by a novel derivative of xanomeline. Cell Research. 18: 1151-1153. 2008
13) Xiaohua Cao, Huimin Wang, Bing Mei, Shuming An, Liang Yin, Phillip L. Wang, and Joe Z. Tsien. Inducible and Selective Erasure of Memories in the Mouse Brain via Chemical-Genetic Manipulation. Neuron. 60(2):353-36. 2008（封面文章）
14) Ai Li, Wen Si, Xinwu Hu, Changjing Liu, Xiaohua Cao*. An optimized recording method to characterize biophysical and pharmacological properties of acid-sensing ion channel. Neurosci Bull. 24(3): 160-165. 2008
15) Xiaohua Cao*, Deheng Wang, Jing Bai, Shaoci Zhou, Yongdi Zhou. Prefrontal modulation of tactile responses in the ventrobasal thalamus of rats. Neuroscience letters. 435:152–157. 2008
16) Yi hui Cui, Wen Si, Liang Yin, Shuming An, Jing Jin, Shining Deng, Xiaohua Cao*. A novel derivative of xanomeline improved memory function in aged mice. Neurosci Bull. 24(4): 251-257. 2008
17) Xiaohua Cao*, Zhenzhong Cui, Ruiben Feng, Ya-Ping Tang, Zhenxia Qin, Bing Mei and Joe Z. Tsien. Maintenance of superior learning and memory function in NR2B transgenic mice during ageing. Eur J Neurosci. 25(6):1815-22. 2007
18) Jing Bai, Deheng Wang, Liang Yin, Shuming An, Shaoci Zhou, Xiaohua Cao*. Properties of tactile responses of neurons in rat thalamic ventroposterolateral nucleus. Neurosci Bull. 23(5): 300-6. 2007
19) Zhiliang Xu, Suzhen Dong, Dan Du, Nan Jiang, Peiqua Sun, Huikun Wang, Liang Yin, Xuliang Zhang, Xiaohua Cao, Xuechu Zhen, Yinghe Hu. Generation and Characterization of hD5 and C-terminal Mutant hD5m Transgenic Rats. Brain Research. S0006-8993(12):00199-0.2012
20) Qiang Li, Xuesheng Liu, Qingwen Zeng, Qingsheng Xue, Xiaohua Cao, Jian Liu, Yu Ren, Buwei Yu. Post-training intra-basolateral amygdala infusions of norepinephrine block sevo?urane-induced impairment of memory consolidation and activity-regulated cytoskeletal protein expression inhibition in rat hippocampus. Neurobiology of Learning and Memory. 96 (3): 492-497. 2011
21) Hongyuan Chu, Qianqian Wu, Shanglin Zhou, Xiaohua Cao, Ao Zhang, Guozhang Jin, Guoyuan Hu, Xuechu Zhen. SKF83959 suppresses excitatory synaptic transmission in rat hippocampus via a dopamine receptor-independent mechanism. Journal of Neuroscience Research. 89(8):1259–1266. August 2011
22) Dong Wang, Liguo Yang, Jingjing Su, Yan Niu, Xiaoping Lei, Juan Xiong, Xiaohua Cao, Yinghe Hu, Bing Mei, Jin-Feng Hu. Attenuation of neurodegenerative phenotypes in Alzheimer-like presenilin 1/presenilin 2 conditional double knockout mice by EUK1001, a promising derivative of xanomeline. Biochemical and Biophysical Research Communications. 410:229-234. July 2011
23) Hong Cao, Yongjing Gao, Wenhua Ren, Tingting Li, Kaizheng Duan, Yihui Cui, Xiaohua Cao, Zhiqi Zhao, Rurong Ji, and Yuqiu Zhang. Activation of Extracellular Signal-Regulated Kinase in the Anterior Cingulate Cortex Contributes to the Induction and Expression of Affective Pain. J Neurosci. 29(10): 3307-3321. 2009
24) Yuanyuan Zhang, Fei Li, Xiaohua Cao, Xingming Jin, Chonghuai Yan, Ying Tian, and Xiaoming Shen. Forepaw Sensorimotor Deprivation in Early Life Leads to the Impairments on SpatialMemory and Synaptic Plasticity in Rats. Journal of Biomedicine and Biotechnology. doi: 10. 1155/2009/919276 .2009
25) Huimin Wang, Ruiben Feng, Fei Li, Xiaohua Cao, & Joe Z. Tsien. CaMKII Activation State Underlies Synaptic Labile phase of LTP and Short-Term Memory Formation. Current Biology 18(20):1546-1554. 2008
26) Xiao hua Ji, Xiaohua Cao, Chunlei Zhang, Zejun Feng, Xuehan Zhang, Lan Ma and Baoming Li. Pre- and post-synaptic β--adrenergic activation enhances excitatory synaptic transmission in layer V/VI pyramidal neurons of the medial prefrontal cortex of rats. Cereb. 18: 1506-1520. (Co-first author) 2008
27) Min H. Cho, Xiaohua Cao, Deheng Wang, Joe Z. Tsien. Dentate gyrus-specific manipulation of [68]-Ca2+/calmodulin-dependent kinase II disrupts memory consolidation. Proc Natl Acad Sci .104(41):16317-22. 2007
28) Fujun Zhang, Xiaomei Feng, Qingwen Zeng, Bo Wang, Wilhelmsen Kevin， Qiang Li, Xiaohua Cao, Buwei Yu. .Sevoflurane induced amnesia inhibits hippocampal Arc expression partially through 5-hydroxytryptamine-7 receptors in the bilateral basolateral amygdala in rats .Neuroscience Letters.562:13-18 2014
29) Yanling She, Jian Xu,Yanhong Duan, Ning Su,Yanan Sun, Xiaohua Cao, Lixing Lao, Ruixin Zhang,Shifen Xu. Possible antidepressant effects and mechanism of electroacupuncture in behaviors and hippocampal synaptic plasticity in a depression rat model.Brain Research.1629:291-297.2015
30) Zheng, Jing; Xu, Da-Feng; Li, Kui; Wang, Hong-Tao; Shen, Peng-Cheng; Lin, Min; Cao, Xiao-Hua; Wang, Rui.Neonatal exposure to fluoxetine and fluvoxamine alteres spine density in mouse hippocampal CA1 pyramidal neurons.International Journal of Clinical and Experimental Pathology, 4(2), pp 162-168, 2011.
31) 薛景景; 李強; 曾慶文; 薛慶生; 曹曉華; 張富軍; 于布為 糖皮質激素逆轉七氟烷對大鼠記憶鞏固的干擾效應。上海醫學, 02期, pp 126-130, 2013/2/25.
32) 徐浩; 王勃; 段燕紅; 曹曉華*; βCaMKⅡ過量表達損害小鼠海馬齒狀回區長時程抑制。華東師范大學學報(自然科學版), 1期, pp 54-62, 2012 冬季
33) 楊李果; 曾慶文; 張旭亮; 曹曉華*. NR1基因敲除對小鼠前額葉腦區LTP的影響。華東師范大學學報(自然科學版), 1(1), pp 47-52, 2012 冬季.
34) 金晶; 張旭亮; 楊李果; 徐浩; 曾慶文; 曹曉華* 母愛剝奪損害大鼠的情緒記憶。華東師范大學學報(自然科學版), 02期, pp 163-170, 2011/3/15.
35) 劉汝清; 段燕紅; 曹曉華* αCaMKII過量表達增強小鼠島葉皮層興奮性突觸傳遞。華東師范大學學報(自然科學版), 04期, pp 94-103, 2011.
36) 張媛媛; 李斐; 金星明; 顏崇淮; 田英; 曹曉華; 沈曉明 生命早期前爪感覺和精細動作剝奪對大鼠海馬Schaffer-CA1通路突觸可塑性的影響。中國兒童保健雜志， 01期， pp 45-48， 2010/1/10.
會議專題報告和文摘
1) 國內會議，特邀報告，曹曉華，學習記憶的分子和神經機制。上海市科協第九屆學術年會 長三角地區神經科學論壇. Sep. 17, 2011, 中國蘇州
2) 國際會議，特邀報告，曹曉華, Role of NMDA NR2B and αCaMKII in learning and memory. 16 th Annual Neuroscience Research Symposium. Jun 26-27,2011，德國科布倫茨.
3) 國內國內，口頭報告，曹曉華，轉基因模式動物表型分析。973項目結題報告會, Oct. 2008, 北京
4) 國際會議，口頭報告，曹曉華 Genetic enhancement of memory and long-term potentiation but not CA1 long-term depression in NR2B transgenic rats. 第三屆全國腦與認知科學研討會暨腦與認知科學國際研討會，Nov 27-Dec 02, 2007，中國云南
5) Bo Wang, Jing Jin, Liguo Yang, Xuliang Zhang, Hao Xu, Xiaohua Cao*. Effect of early maternal deprivation on emotion, memory and synaptic plasticity in rats. The 9th Biennial Conference of the Chinese Society for Neuroscience, 2011, p. 499
6) Hao Xu, Bo Wang, Pengcheng Yin, Jing Ma, Jiao Han, Xiaohua Cao*. βCaMKII overexpression impairs long-term depression of dentate gyrus and memory in mice. The 9th Biennial Conference of the Chinese Society for Neuroscience, 2011, p. 86
7) Yanhong Duan, Wen Si, Jing Ma, Bo Wang, Xiaohua Cao*. Effects of NR2A overexpression on prefrontal synaptic plasticity and prefrontal cortex-related memory. The 9th Biennial Conference of the Chinese Society for Neuroscience, 2011, p. 78
8) Yihui Cui, Jing Jin, Liang Yin, Dan Du, Shining Deng, Hao Xu, Xiaohua Cao*. Forebrain NR2B overexpression facilitating the prefrontal synaptic plasticity and enhancing working memory function. The 8th Biennial Conference of the Chinese Society for Neuroscience, 2009, p. 266.
9) Shuming An, Jing Jin, Liguo Yang, Qingwen Zeng, Hao Xu, Ruqing Liu, Xuliang Zhang, Xiaohua Cao*. Forebrain overexpression of αCaMKII impairs amygdala long term depression and behavioral flexibility. The 8th Biennial Conference of the Chinese Society for Neuroscience, 2009, p. 143.
10) Xuliang Zhang, Wen Si, Ruqing Liu, Xiaohua Cao*. Euk1001 improved age-related memory deficit. The 8th Biennial Conference of the Chinese Society for Neuroscience, 2009, p. 83.
11) Wen Si, Shining Deng; Zhenzhong Cui; Joe Z. Tsien; Xiaohua Cao*. Overexpression of NR2A subunits impaired prefrontal synaptic plasticity and prefrontal cortex-related memory. The 8th Biennial Conference of the Chinese Society for Neuroscience, 2009, p. 83.
12) Yihui Cui, Liang Yin, Jing Jin, Dan Du, Hao Xu, Liguo Yang, Xiaohua Cao*. Forebrain NR2B overexpression facilitating the prefrontal synaptic plasticity and enhancing working memory function. The 39th annual meeting of the Society for Neuroscience, 2009, in USA
13) Wen Si, Jing Bai, Zhenzhong Cui, Joe Z. Tsien, Xiaohua Cao*. Study on synaptic plasticity of amygadala and fear memory in NR2A transgenic mice. The 7th Biennial Conference of the Chinese Society for Neuroscience, 2007, p. 209.
14) Yihui Cui, Dong Wang, Wen Si, Wen Lv, Yan Niu, Xiaoping Lei, Yinghe Hu, Xiaohua Cao*. Enhancement of memory function in aged mice by a novel derivative of xanomeline. The 37 th annual meeting of the Society for Neuroscience, 2007, in USA
15) *Xiaohua Cao*; Jing Ma; Yanhong Duan; Zhenxia Qin; Jiayue Wang; Meichen Xu; Siqi Zhou，αCaMKII overexpression impairs behavioral flexibility and NMDAR dependent LTD in the medial prefrontal cortex.The 6th FAONS Congress & The 11th Biennial Conference of CNS, 2015/9/20-2015/9/23, 烏鎮, 2015/9/22, 墻報展示.
16) *Xiaohua Cao*; Pengcheng Yin; Qi Wang，βCaMKII overexpression impairs long-term depression of dentate gyrus and behavioral flexibility。The 6th FAONS Congress & The 11th Biennial Conference of CNS, 2015/9/20-2015/9/23, 烏鎮, 2015/9/22, 墻報展示.
教材與論著（參與編寫）
1) 曹曉華。學習記憶的分子和神經機制，《生理科學進展》，第一版，高等教育出版社，王建軍、王曉民主編。2014.8 P：695-708。
2) 周紹慈、曹曉華。情緒行為的神經生理學基礎，《生理學》，第三版，第十二章，人民衛生出版社，張鏡如、姚泰主編。2001.12 P:476-500。
3) 周紹慈、曹曉華。中樞神經系統對運動機能的控制和調節、中樞神經系統的感覺機能。見：《人體及動物生理學》，第二版，第二、三節，高等教育出版社，王玢、左明雪主編。2001.07，69-138。
4) 周紹慈、曹曉華。杏仁核群的功能，見:《當代生物科學前沿》，北京致公出版社。2000, 538-539。
5) 曹曉華。情緒行為的神經生理學基礎，《生理學》，第12章，第四版，人民衛生出版社。待出版。