周曉明博士 感覺整合與可塑性
腦功能基因組學教育部重點實驗室PI
生命科學學院 教授
辦公電話：021-62604169
Email: xmzhou@bio.ecnu.edu.cn
研究方向
主要研究領域為感覺系統神經生物學。采用分子神經生物學、神經電生理學及行為學等技術和方法，以聽覺系統為模型研究腦感覺信息處理機制、多通道感覺信息整合及功能可塑性、可塑性和行為的關系等。
個人簡歷
1995-09~1998-07 華東師范大學 博士
1998-08~2005-01 University of Missouri-Columbia, USA 博士后
2005-02~至今 華東師范大學 教授
2006-01~2007-12 University of California-San Francisco, USA 合作研究
2009-01~2011-08 University of California-San Francisco, USA 合作研究
學術任職/人才獲獎
上海市生理科學會 理事
上海市青年科技啟明星、啟明星(跟蹤)、上海市“浦江人才”、教育部“新世紀優秀人才”。“中樞聽覺可塑性及其機制”獲教育部高等學校科學技術獎(自然科學獎)二等獎(2015.2)。
代表性成果
1.Zhu X, Liu X, Wei F, Wang F, Merzenich MM, Schreiner CE, Sun X, Zhou X (2016) Perceptual training restores impaired cortical temporal processing due to lead exposure. Cereb Cortex 26:334-345 (Corresponding author)Zhu X, Liu X, Wei F, Wang F, Merzenich MM, Schreiner CE, Sun X, Zhou X (2016) Perceptual training restores impaired cortical temporal processing due to lead exposure. Cereb Cortex 26:334-345 (Corresponding author)
2.hou X, Lu YF, Darling RD, Simpson KL, Zhu X, Wang F, Yu L, Sun X, Merzenich MM, Lin RC (2015) Behavioral training reverses global cortical network dysfunction induced by perinatal antidepressant exposure. Proc Natl Acad Sci USA 112:2233-2238 (Co-corresponding author)Zhou X, Lu YF, Darling RD, Simpson KL, Zhu X, Wang F, Yu L, Sun X, Merzenich MM, Lin RC (2015) Behavioral training reverses global cortical network dysfunction induced by perinatal antidepressant exposure. Proc Natl Acad Sci USA 112:2233-2238 (Co-corresponding author)
3.Zhu X, Wang F, Hu H, Sun X, Kilgard MP, Merzenich MM, Zhou X (2014) Environmental acoustic enrichment promotes recovery from developmentally degraded auditory cortical processing. J Neurosci34:5406-5415 (Corresponding author)
4.Zhang Y, Zhao Y, Zhu X, Sun X, Zhou X (2013) Refining cortical representation of sound azimuths by auditory discrimination training. J Neurosci 33:9693-9698 (Corresponding author)
5.Zhou X, Merzenich MM (2012) Environmental noise exposure degrades normal listening processes. Nat Commun 10.1038/ncomms1849, 3:843 (Corresponding author)
6.Guo F, Zhang J, Zhu X, Cai R, Zhou X, Sun X (2012) Auditory discrimination training rescues developmentally degraded directional selectivity and restores mature expression of GABAA and AMPA receptor subunits in rat auditory cortex. Behav Brain Res 229:301-307(Co-corresponding author)
7.Zhou X, Panizzutti R, de Villers-Sidani É, Madeira C, Merzenich MM (2011) Natural restoration of critical period plasticity in the juvenile and adult primary auditory cortex. J Neurosci 31:5625-5634 (Corresponding author)
8.Pan Y, Zhang J, Cai R, Zhou X, Sun X (2011) Developmentally degraded directional selectivity of the auditory cortex can be restored by auditory discrimination training in adults. Behav Brain Res 225:596-602 (Co-corresponding author)
9.Zhou X, de Villers-Sidani É, Panizzutti R, Merzenich MM (2010) Successive-signal biasing for a learned sound sequence. Proc Natl Acad Sci USA 107:14839-14844 (Co-corresponding author)
10.de Villers-Sidani É, Alzghoul L, Zhou X, Simpson KL, Lin RCS, Merzenich MM (2010) Recovery of age-related changes in the rat primary auditory cortex with operant training. Proc Natl Acad Sci USA107:13900-13905
11.Cai R, Zhou X, Guo F, Xu J, Zhang J, Sun X (2010) Maintenance of enriched environment-induced changes of auditory spatial sensitivity and expression of GABA(A), NMDA, and AMPA receptor subunits in rat auditory cortex. Neurobiol Learn Mem94:452-460
12.Zhou X, Merzenich MM (2009) Developmentally degraded cortical temporal processing restored by training. Nat Neurosci 12:26-28 (Corresponding author)
13.Zhou X, Merzenich MM (2008) Enduring effects of early structured noise exposure on temporal modulation in the primary auditory cortex. Proc Natl Acad Sci USA 105:4423-4428 (Co-corresponding author)
14.Zhou X, Nagarajan N, Mossop BJ, Merzenich MM (2008) Influences of un-modulated acoustic inputs on functional maturation and critical-period plasticity of the primary auditory cortex. Neurosci154:390-396
15.Zhou X, Merzenich MM (2007) Intensive training in adults refines A1 representations degraded in an early postnatal critical period. Proc Natl Acad Sci USA 104:15935-15940
16.Zhou X, Jen PH (2007) Corticofugal modulation of multi-parametric auditory selectivity in the midbrain of the big brown bat. J Neurophysiol 98:2509-2516 (Corresponding author)
17.Zhou X, Jen PHS (2005) Corticofugal modulation of directional sensitivity in the midbrain of the big brown bat, Eptesicus fuscus, Hear Res 203:201-215
18.Jen PHS, Zhou X (2003) Corticofugal modulation of amplitude domain processing in the midbrain of the big brown bat, Eptesicus fuscus, Hear Res 184:91-106
19.Zhou X, Jen PHS (2002) The role of GABAergic inhibition in shaping directional selectivity of bat inferior collicular neurons determined with temporally patterned pulse trains, J Comp Physiol 188:815-826
20.Jen PHS, Zhou X, Zhang JP, Chen QC, Sun XD (2002) Brief and short-term corticofugal modulation of acoustic signal processing in the bat midbrain, Hear Res 168:196-207
21.Zhou X, Jen PHS (2002) The effect of sound duration on rate-intensity functions of inferior collicular neurons in the big brown bat, Eptesicus fuscus, Hear Res 166:124-135
22.Jen PHS, Zhou X, Wu CH (2001) Temporally patterned sound pulse trains affect intensity and frequency sensitivity of inferior collicular neurons of the big brown bat, Eptesicus fuscus, J Comp Physiol 187:605-616
23.Zhou X, Jen PHS (2001) The effect of sound intensity on duration tuning characteristics of bat inferior collicular neurons, J Comp Physiol 187:63-73
24.Zhou X, Jen PHS (2000) Brief and short-term corticofugal modulation of subcortical auditory responses in the big brown bat, Eptesicus fuscus, J Neurophysiol 84:3083-3087
25.Zhou X, Jen PHS (2000) Neural inhibition sharps spatial selectivity of bat inferior collicular neurons, J Comp Physiol 186:389-398
26.Jen PHS, Zhou X (1999) Temporally patterned sound trains affect duration tuning characteristics of bat inferior collicular neurons, J Comp Physiol185:471-478