李曉濤 博士 蛋白質降解研究

腦功能基因組學教育部重點實驗室PI
生命科學學院 教授
辦公電話：021-54345018
Email: xiaotaol@gmail.com

研究方向
REGγ蛋白酶體的功能、調控、及其介導蛋白質降解的分子機制。

個人簡歷
1989      重慶醫科大學, M.D
1989-1992 重慶醫科大學附屬第一醫院，住院醫師，主治醫師
1992-1995 美國德克薩斯大學生物醫學研究院 Research Fellowship
1995-2001 美國UT M.D. Anderson癌癥中心Graduate Research Assistant。
2001      美國德克薩斯大學生物醫學研究院, M.D. Anderson癌癥中心Ph.D.
2001-2005  美國Baylor醫學院, Postdoctoral Associate。
2005-2006  美國Baylor醫學院, Instructor.
2006-2007.8月 美國Baylor醫學院, Assistant Professor.
2007.8月 至今 華東師范大學，教授

學術任職/人才獲獎
Oxidative Medicine and Cellular Longevity雜志   編委
Annals of Hematology & Oncology 雜志        編委
上海生化與分子生物學學會               理事

代表性成果

1. Ji L, Xu J1, Liu J, Amjad A, Zhang K, Liu Q, Zhou L, Xiao J, Li X*., (2015), Mutant p53 promotes tumor cell malignancy by both positive and negative regulation of the transforming growth factor β (TGF-β) pathway. J Biol Chem. ;290(18):11729 -40.(影響因子：4.573)
2. Li L, Dang Y, Zhang J, Yan W, Zhai W, Chen H, Li K, Tong L, Gao X, Amjad A, Ji L, Jing T, Jiang Z, Shi K, Yao L, Song D, Liu T, Yang X, Yang C, Cai X, Xu W, Huang Q, He J, Liu J, Chen T, Moses RE, Fu J, Xiao J, Li X*.,(2015), REGγ is critical for skin carcinogenesis by modulating the Wnt/β-catenin pathway.(in press)
3. Li X*, Moses RE, Jin J, Cao W, Caulin C.,(2014), Stresses, aging, and age-related disorders. Oxid Med Cell Longev. 2014;2014:320564.(影響因子：3.516)
4. Liu S, Lai L, Zuo Q, Dai F, Wu L, Wang Y, Liu M, Yi Z, Xiao J, Li X*. PKA turnover by the REGγ-proteasome modulates FoxO1 cellular activity and VEGF-induced angiogenesis. J Mol Cell Cardiol. 2014 Feb 20; 72C: 28-38. （影響因子：5.166）
5. Shi J, Wong J, Piesik P, Fung G, Zhang J, Jagdeo J, Li X, Jan E, Luo H. Cleavage of sequestosome 1/p62 by an enteroviral protease results in disrupted selective autophagy and impaired NFKB signaling. Autophagy. 2013 Aug 13;9 (10).（影響因子：12.042）
6. Ali A,  Wang Z,  Ji L, Liu J, Li L, Yang Y, Wang Y, Zhou L,  Guo L, Wang H, Chen J, Caulin C, Myers JN, Fu J, Xiao J, Zhang B, Li X*. WT-p53/TGF-β signaling and mutant-p53 differentially regulates REGγ to target ubiquitin/ATP-independent REGγ-proteasome pathway during cancer progression. Nature Communication 2013 4:2667 （影響因子：10.015）
7. Dong S, Jia C, Zhang S, Fan G, Xiao W, Shan P, Sun L, Li L, Zheng Y, Liu J, Li Y, Wei H, Hu C, Zhang W, Li Q, Liu J, Jia F, Mo Q, Edwards DP, Huang S, Chan L, O'Malley BW, Li X* and Wang C* The REGγ Proteasome Regulates Hepatic Lipid Metabolism through Inhibition of Autophagy. Cell Metabolism 2013 Sep 3;18(3):380-91. （影響因子：17.3）
8. Li L, Zhao D, Wei H, Yao L, Dang Y, Amjad A, Xu J, Liu J, Guo L, Li D, Li Z, Zuo D, Zhang Y, Liu J, Huang S, Jia C, Wang L, Wang Y, Xie Y, Luo J, Zhang B, Luo H, Donehower LA, Moses RE, Xiao J, O'Malley BW, Li X*. REGγ deficiency promotes premature aging via the casein kinase 1 pathway. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11005-10. （影響因子：9.737）
9. Liu J, Wang Y, Li L, Zhou L, Wei H, Zhou Q, Liu J, Wang W, Ji L, Shan P, Wang Y, Yang Y, Jung SY, Zhang P, Wang C, Long W, Zhang B, Li X*. Site-specific acetylation of the proteasome activator REGγ directs its heptameric structure and functions. J Biol Chem. 2013 Jun 7;288(23):16567-78 （影響因子：4.651）
10. Redfern AD, Colley SM, Beveridge DJ, Ikeda N, Epis MR, Li X, Foulds CE, Stuart LM, Barker A, Russell VJ, Ramsay K, Kobelke SJ, Li X, Hatchell EC, Payne C, Giles KM, Messineo A, Gatignol A, Lanz RB, O'Malley BW, Leedman PJ. RNA-induced silencing complex (RISC) Proteins PACT, TRBP, and Dicer are SRA binding nuclear receptor coregulators. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6536-41. （影響因子：9.737）
11. Jing He, Long Cui, Yu Zeng, Guangqiang Wang, Li X*. (2012).  REGgamma is associated with multiple oncogenic pathways in human cancers. BMC Cancer. Feb 23; 12(1):75. （影響因子：3.333）
12. Wu Y, Wang L, Zhou P, Wang G, Li X*. (2011).  Regulation of REGg cellular distribution and function by SUMO modification. Cell Research.  2011 May; 21(5):807-16. （影響因子：10.526）
13. Gao G, Wong J, Zhang J, Mao I, Shravah J, Wu Y, Xiao A, Li X*, Luo H. (2010). Proteasome Activator REGg Enhances Coxsackieviral Infection via Facilitating p53 Degradation. J. Virol. 84 (21): 11056-11066. （影響因子：5.076）
14. Liu J, Yu G., Zhao P., Wang C., Luo H., Long W., Wang Y., Zhao Y., Tsai M., O'Malley B.W. and Li X*. (2010).  REGγ modulates p53 activity by regulating its cellular localization. J. Cell Science. 123 (pt23): 4076-84.（影響因子：5.877）
15. Yu G, Zhao Y, He J, Mukherjee A, Mao CA, Li M, and Li X*. (2008). Comparative analysis of REGγ expression augurs functional implication. J. Mol. Cell. Biol. Aug; 2(4):192-8.（影響因子：7.308）
16. Ivy Mao, Jian Liu, Li X*, Honglin Luo. (2008). REGg, A Proteasome Activator and Beyond? Cell and Mol Life Sci. Dec;65(24):3971-80.（影響因子：5.615）
17. Li X*, Larbi Amazit, Weiweng Long, David M. Lonard, John J. Monaco and
18. O’Malley B.W. (2007). Proteolytic turnover of p21 by the REGgamma-proteasome pathway. Mol. Cell, 26,  831-842.（影響因子：15.28）
19. Li X*., Lonard D., Jung S.Y., Malovannaya A., Feng Q., Qin J., Tsai S. Y., Tsai M-J., and O’Malley B.W. (2006).  The SRC-3/AIB1 coactivator is degraded in an ubiquitin- and ATP-independent manner by the REGgamm-proteasome  Cell. 124, 381-392.（影響因子：31.957）