趙政 博士 神經藥理與毒理研究

腦功能基因組學教育部重點實驗室PI
辦公電話：021-62238005
Email: zzhao@brain.ecnu.edu.cn

研究方向
藥理學和藥理蛋白組學在中樞神經系統藥物開發中的應用
新藥藥效動力學和藥代動力學的研究
藥理蛋白組學在中樞神經系統藥物發展中的應用

個人簡歷
2011年12月---至今         華東師范大學腦功能基因組學研究所  研究員
2005年3月---2011年12月  華東師范大學腦功能基因組學研究所 副研究員
2003年6月---2005年2月   英國牛津大學醫學院 博士后
2003年6月                香港中文大學 化學病理學 博士

學術任職/人才獲獎
上海市“浦江人才計劃”

代表性成果

1. Shuyan Wang, Yale Duan, Diansan Su, Wen Li, Juan Tan, Danqing Yang, Weili Wang, Zheng Zhao*, Xiangrui Wang* Delta opioid peptide [d-Ala2, d-Leu5] enkephalin (DADLE) triggers postconditioning against transient forebrain ischemia. European Journal of Pharmacology 2011, 658 (2-3) 100-104
2. Gu, F., Shi, J.-T., Wen, Y., Fan, H., Hu, J.-F., Hu, Y.-H. and Zhao, Z.,* Translational responses of NR2B overexpression in the cerebral cortex of transgenic mice: a liquid chromatography-based proteomic approach. Brain Research 2009; 1250:1-13
3. Zhu, M.-J., Gu, F., Shi, J.-T., Hu, J.-F., Hu, Y.-H. and Zhao, Z.,* Increased oxidative stress and astrogliosis responses in conditional double knockout mice of Alzheimer-like presenilin-1 and presenilin-2. Free Radical Biology & Medicine 2008; 45:1493–1499
4. Gu, F., Zhu, M.-J., Shi, J.-T., Hu, Y.-H. and Zhao, Z.,* Enhanced oxidative stress is an early event during development of Alzheimer-like pathologies in presenilin conditional knock-out mice. Neuroscience Letters 2008; 440:44-48
5. Zhu, M.-J., Sun, L.-J., Liu, Y.-Q., Feng, Y.-L., Tong, H.-T., Hu, Y.-H. and Zhao, Z.,* Blood F2-isoprostanes are significantly associated with the abnormalities of lipid status in rats with steatosis. World Journal of Gastroenterology 2008; 14:4677-4683
6. Wu, S.-B., Wen, Y., Li, X.-W., Zhao, Y., Zhao, Z.,* Hu, J.-F.,* Chemical constituents from the fruits of Sonneratia caseolaris and Sonneratia ovata (Sonneratiaceae). Biochemical Systematics and Ecology 2009; 37:1-5
7. Wu, S.-B., Fei, P., Wen, Y., Zhang, H.-F.,* Zhao, Z.,* Hu, J.-F.,* Antiproliferrative and apoptotic activities of linear furocoumarins from Notopterygium incisum on cancer cell lines. Planta Medica 2010; 76:82-85
8. Li, X.-W., Guo, Z.-T., Zhao, Y., Zhao, Z., Hu, J.-F.,* Chemical constituents from Saussurea cordifolia. Phytochemistry 2010. 71:682–687
9. Zheng Zhao and Yinghe Hu.* Genome-Wide Expression Profiles of Amygdala and Hippocampus in Mice After Fear Conditioning. In Genomics, Proteomics, and the Nervous System, Advances in Neurobiology, 2011, Volume 2, Part 3, 303-329, DOI: 10.1007/978-1-4419-7197-5_12 (Book Chapter)
10. Yale Duan, Shuyan Wang, Qinwen Ceng, Diansan Su, Wen Li, Xiangrui Wang* and Zheng Zhao* Astroglial reaction to delta opioid peptide [d-Ala2, d-Leu5] enkephalin (DADLE) confers neuroprotection against global ischemia in the adult rat hippocampus. Neuroscience 2011, 192:81-90
11. Suzhen Dong, Qingwen Zeng, E. Siobhan Mitchell, Jin Xiu, Yale Duana, Chunxia Li, Jyoti K. Tiwari,*, Yinghe Hu, Xiaohua Cao,*, Zheng Zhao,* Curcumin enhances neurogenesis and cognition in aged rats: implications for transcriptional interactions related to growth and synaptic plasticity. PLoS ONE 2012, 7(2): e31211.
12. Dong S, Duan Y, Hu Y, Zhao Z*. Advances in the pathogenesis of Alzheimer's disease: a re-evaluation of amyloid cascade hypothesis. Transl Neurodegener, 2012, 1: 18
13. Duan Y, Dong S, Gu F, Hu Y, Zhao Z*. Advances in the Pathogenesis of Alzheimer's Disease: Focusing on Tau-Mediated Neurodegeneration. Transl Neurodegener, 2012, 1: 24
14. Yale Duan, Rui Zhang,Min Zhang, Lijuan Sun, Suzhen Dong, Gang Wang，Jun Zhang, Zheng Zhao*. Metformin inhibits food intake and NPY gene expression in the hypothalamus. Neural Regeneration Research 2013, 8(25):2379-2388
15. Ming-Liang Ma, Ming Li, Jiao-Jiao Gou, Tian-Yu Ruan, Hai-Shan Jin, Ling-Hong Zhang,Liang-Chun Wu, Xiao-Yan Li, Ying-He Hu, Ke Wenc, Zheng Zhao* Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor. Bioorganic & Medicinal Chemistry 2014(24):6117
16. Shouning Yang, Wei Shi, Dong Xing, Zheng Zhao**, Fengping Lv, Liping Yang, Yushe Yang**, Wenhao Hu* Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. European Journal of Medicinal Chemistry 2014(86):133
17. Tao Jia, Li Zhang, Yale Duan, Min Zhang, Gang Wang, Jun Zhang and Zheng Zhao* The differential susceptibilities of MCF-7 and MDA-MB-231 cells to the cytotoxic effects of curcumin are associated with the PI3K/Akt-SKP2-Cip/Kips pathway. Cancer Cell International 2014(14):126